Use of Promethazine and Meperidine as Premedicants in Asthmatics before Initiation of Surgery: An Interim Report
Patients with bronchial asthma usually land up for surgery and pose a significant challenge as far as their anesthetic management is concerned. Most of these patients either take medicines or else are in a comparatively controlled state. Different protocols have been suggested for such cases such as corticosteroids, long-term β2 agonists, leukotriene receptor antagonists and theophylline sustained-release preparations.
2. Adam K, Oswald I. The hypnotic effects of an antihistamine: promethazine. Br J Clin Pharmacol. 1986;22(6):715-7.
3. Taylor G, Houston JB, Shaffer J, Mawer G. Pharmacokinetics of promethazine and its sulphoxide metabolite after intravenous and oral administration to man. Br J Clin Pharmacol. 1983;15(3):287-93.
4. Cantisani C, Ricci S, Grieco T, Paolino G, Faina V, Silvestri E, et al. Topical promethazine side effects: our experience and review of the literature. Biomed Res Int. 2013;2013:151509.
5. Latta KS, Ginsberg B, Barkin RL. Meperidine: a critical review. Am J Therapeutics. 2002;9(1):53-68.
6. Chen A, Ashburn MA. Cardiac Effects of Opioid Therapy. Pain Med. 2015;16 Suppl 1:S27-31.
7. Kredo T, Onia R. Pethidine--does familiarity or evidence perpetuate its use? South Afr Med J. 2005;95(2):100-1.
8. Yamanaka T, Sadikot RT. Opioid effect on lungs. Respirology. 2013;18(2):255-62.
9. Karlsson JA, Lanner AS, Persson CG. Airway opioid receptors mediate inhibition of cough and reflex bronchoconstriction in guinea pigs. J Pharmacol Exper Thera. 1990;252(2):863-8.
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