Sample Size Calculation Guide - Part 5: How to calculate the sample size for a superiority clinical trial

  • Ahmed Negida ORCID Mail Faculty of Medicine, Zagazig University, Zagazig, El-Sharkia, Egypt.
  • Nadien Khaled Fahim ORCID Clinical Program, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
  • Yasmin Negida ORCID Faculty of Medicine, Zagazig University, Zagazig, El-Sharkia, Egypt
  • Hussien Ahmed ORCID Faculty of Medicine, Zagazig University, Zagazig, El-Sharkia, Egypt.

Abstract

In the previous educational articles, we explained how to calculate the sample size for a rate or a single proportion, for an independent cohort study, for an independent case-control study, and for a diagnostic test accuracy study. In this article, we explain how to calculate the sample size for a superiority clinical trial.

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References

1. Fahim NK, Negida A. Sample size calculation guide - part 1: how to calculate the sample size based on the prevalence rate. Adv J Emerg Med. 2018;2(4):e50.
2. Fahim NK, Negida A. Sample size calculation guide - part 2: how to calculate the sample size for an independent cohort study. Adv J Emerg Med. 2019;3(1);e12.
3. Fahim NK, Negida A, Fahim AK. Sample size calculation guide - part 3: how to calculate the sample size for an independent case-control study. Adv J Emerg Med. 2019;3(2):e20.
4. Negida A, Fahim NK, Negida Y. Sample size calculation guide - part 4: how to calculate the sample size for a diagnostic test accuracy study based on sensitivity, specificity, and the area under the roc curve. Adv J Emerg Med. 2019;3(3):e33.
5. Odekerken VJ, van Laar T, Staal MJ, Mosch A, Hoffmann CF, Nijssen PC, et al. Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson's disease (NSTAPS study): a randomised controlled trial. Lancet Neurol. 2013;12(1):37-44.
Published
2019-08-29
How to Cite
1.
Negida A, Fahim N, Negida Y, Ahmed H. Sample Size Calculation Guide - Part 5: How to calculate the sample size for a superiority clinical trial. Adv J Emerg Med. 3(4):e49.
Section
Educational Notes in Research Methodology and Medical Statistics