Interferon beta-1a as a Candidate for COVID-19 Treatment; An Open-Label Single-Arm Clinical Trial

  • Pooya Payandemehr ORCID Mail Prehospital and Hospital Emergency Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Morteza Azhdarzadeh ORCID Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  • Hooman Bahrami-Motlagh ORCID Radiology Department, Loghman Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Azar Hadadi ORCID Department of Infectious Diseases, Tehran University of Medical Sciences, Tehran, Iran
  • Farhad Najmeddin ORCID Clinical Pharmacy Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  • Shaghayegh Shahmirzaei ORCID Trauma and Surgery Research Center, Sina hospital, Tehran University of Medical sciences, Tehran, Iran
  • Marzieh Pazoki ORCID Department of Pulmonary Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  • Mehran Sotoodehnia ORCID Prehospital and Hospital Emergency Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Reza Rahimian ORCID McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada
Keywords:
Antiviral Agents, Clinical Trials as Topic, COVID-19, Interferon beta-1a

Abstract

Introduction: Since December 2019, an outbreak of Covid-19 has caused growing concern in multiple countries. Researchers around the world are working to find a treatment or a vaccine for Covid-19 and different treatment approaches have been tested in this regard. Objective: This study was designed and conducted to assess the possible efficacy of Interferon beta-1a as a safe and efficient candidate for Covid-19 treatment. Methods: This is an investigator-initiated, open-label, single-arm clinical trial. Twenty patients with suspected Covid-19, who were admitted to Sina hospital in Tehran, Iran, with moderate to severe symptoms, from 6 to 10 March, 2020, were enrolled. Patients were treated with antiviral and hydroxychloroquine combination therapy, along with subcutaneous Interferon beta-1a for 5 consecutive days. Baseline characteristics and findings during the course of admission and 5 days after discharge were recorded for all the patients. Results: In total, 20 patients with suspected Covid-19 were included in this study, 12 (60%) of which were male. The median (Interquartile (IQ) range) of patients’ age was 55.5 (43-63.5). The most common symptom of the patients at onset of disease was fever. The median (IQ range) of duration of hospital stay was 5.0 (3-6) days. Only 2 cases were admitted to ICU. At the time of follow-up, 15 (94%) patients reported that they generally felt good and had oral tolerance, 1 patient had suffered from dyspnea, 5 patients had suffered from cough, none of them had experienced fever and no case of re-admission or death was reported after discharge. Conclusions: Results of the current study are in favor of using Interferon beta-1a in addition to recommended antiviral treatment in Covid-19 patients.

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Published
2020-05-26
How to Cite
1.
Payandemehr P, Azhdarzadeh M, Bahrami-Motlagh H, Hadadi A, Najmeddin F, Shahmirzaei S, Pazoki M, Sotoodehnia M, Rahimian R. Interferon beta-1a as a Candidate for COVID-19 Treatment; An Open-Label Single-Arm Clinical Trial. Adv J Emerg Med. 4(2s):e51.
Section
Original article